Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Efficacy of sodium creatine phosphate in pediatric viral myocarditis and cellular immune functions

Xinhong Liu¹, Junhua Li², Rui Li³, Hongbo Zhang³, Keya Chen²

¹Department of Pediatrics, Dezhou Traditional Chinese Medicine Hospital, Dezhou, China; ²Department of Pediatrics, The Second People's Hospital of Dongying, Dongying, China; ³Department of Pediatrics, Lingcheng District Hospital of Traditional Chinese Medicine, Dezhou, Shandong, China.

For correspondence:- Keya Chen Email: wonderful_cky@163.com Tel:+8618766731425

Accepted: 6 February 2024 Published: 29 February 2024

Citation: Liu X, Li J, Li R, Zhang H, Chen K. Efficacy of sodium creatine phosphate in pediatric viral myocarditis and cellular immune functions. Trop J Pharm Res 2024; 23(2):473-480 doi: 10.4314/tjpr.v23i2.30

© 2024 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To investigate the effectiveness of sodium creatine phosphate (SCP) in pediatric viral myocarditis, and cellular immune functions.

Methods: Clinical data of 83 children with viral myocarditis admitted to Dezhou Traditional Chinese Medicine Hospital, China between May 2019 and June 2021 were collected and randomly assigned to control (n = 41) and study groups (n = 42). Control group (CNG) received conventional treatment for 14 days, including intravenous drip of sodium fructose diphosphate, vitamin C, and ribavirin, with the addition of prednisone if necessary. Study group (SG) received SCP in addition to conventional treatment for 14 days. Clinical efficacy, cardiac function, inflammatory and immune markers, myocardial injury, and adverse effects at the end of treatment were determined.

Results: Results indicated a significantly higher total effective rate in study group (95.24 %) compared to control group (78.05 %) (p < 0.05). Study group demonstrated significantly lower heart rates and improved cardiac output, stroke volume, and left ventricular ejection fraction after 14 days of treatment compared to control group (p < 0.05). Furthermore, study group exhibited significant reduction in levels of inflammatory markers (p < 0.05), enhanced cellular immune markers (p < 0.05), and reduced myocardial injury and remodeling markers (p < 0.05). Both groups showed similar incidence of adverse reactions.

Conclusion: Sodium creatine phosphate (SCP) is effective in treating pediatric viral myocarditis, enhances cardiac function, restores cellular immune function, reduces inflammation, and minimizes myocardial damage and remodeling. There will be need to evaluate the long-term efficacy and prognosis of SCP in treating pediatric viral myocarditis in the future.

Keywords: Viral myocarditis, Sodium creatine phosphate, Cardiac function, Cellular immune function, Myocardial remodeling